心血管疾病
机制与干预研究 Mechanisms and Interventions in Cardiovascular Disease

导师简介 Principal investigator

同济大学长聘特聘教授、博士生导师、生物医药与技术系系主任；国家杰出青年科学基金获得者。 Distinguished Professor and Doctoral Supervisor, Chair of the Department of Biomedical Science and Technology, Tongji University; recipient of the National Science Fund for Distinguished Young Scholars.

项耀祖教授获英国帝国理工学院分子血液学博士学位，后在美国耶鲁大学开展博士后研究。实验室长期致力于心血管病发生机制及中西医防治研究，先后主持8项国家级项目，在 Blood、JCI、PNAS 等国际期刊发表论文50余篇，获授权发明专利4项。 Professor Yaozu Xiang received his PhD in Molecular Haematology from Imperial College London and completed postdoctoral training at Yale University. His laboratory investigates cardiovascular disease mechanisms and integrative approaches to prevention and treatment. He has led eight national research projects, published more than 50 articles in journals including Blood, JCI, and PNAS, and holds four authorized invention patents.

查看导师官方介绍 Official faculty profile （新窗口打开） (opens in a new tab)

研究方向 Research

1. 01

   心血管生物学与基础医学 Cardiovascular biology and basic medicine

2. 02

   心血管病发生机制及干预 Mechanisms and interventions in cardiovascular disease

3. 03

   证候生物学基础与中药药理学 Biological basis of traditional Chinese medicine syndromes and pharmacology of Chinese medicine

精选论文 Selected papers

选自导师官方介绍页所列代表论文，按年份由近及远排列。 Representative papers from the official faculty page, in reverse chronological order.

1. 2026

   Nature Communications

   Mitochondria-derived vesicles with bioenergetic units from brown adipose tissue attenuate cardiac remodeling post-myocardial infarction.

   Shi T, Chen F, Xu Y, Jiang K, Deng R, Yang X, Chen Y, Che W, Hwa J, Wang D, Xiang Y*.

2. 2025

   European Heart Journal · ehaf049

   Periodontitis-related myocardial fibrosis by expansion of collagen-producing SiglecF+ neutrophils.

   Wang X, Xu Y, Yu C, Deng R, Chen Y, Jiang K, Liang J, Hu C, Yang X, Zhang B, Yuan X, Pan C, Wang D, Sun Y*, Xiang Y*.

3. 2025

   Cardiovascular Diabetology · 24(1):184

   Cardiomyocyte-specific NHE1 overexpression confers protection against myocardial infarction during hyperglycemia.

   Jiang K, Su F, Deng R, Xu Y, Qin A, Yuan X, Xing D, Chen Y, Wang D, Shen L, Hwa J, Hou L*, Xiang Y*.

4. 2024

   Biomaterials · 305:122466

   Brazilin-Ce nanoparticles attenuate inflammation by de/anti-phosphorylation of IKKβ.

   Li S, Wang K, Jiang K, Xing D, Deng R, Xu Y, Ding Y, Guan H, Chen LL, Wang D, Chen Y*, Bu W*, Xiang Y*.

5. 2023

   Cell Reports · 42(10):113174

   A transient wave of Bhlhe41+ resident macrophages enables remodeling of the developing infarcted myocardium.

   Xu Y, Jiang K, Su F, Deng R, Cheng Z, Wang D, Yu Y, Xiang Y*.

6. 2022

   JCI · 132(1):e151268

   Gasdermin D inhibition confers antineutrophil-mediated cardioprotection in acute myocardial infarction.

   Jiang K, Tu Z, Chen K, Xu Y, Chen F, Xu S, Shi T, Qian J, Shen L, Hwa J, Wang D, Xiang Y*.

星号沿用官方列表中的通讯作者标记。 Asterisks follow corresponding-author marks on the official list.

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